A larger, randomized, multiarmed clinical trial evaluating the effects of pentoxifylline as an adjunctive treatment modality may be of benefit since even a small positive effect in altering the natural history of CME related to CRVO may be of value for these patients. Visual acuity does not appear to change significantly. Pentoxifylline has a favorable adverse effect profile, and can reduce CME in eyes with CRVO. See the complete profile on LinkedIn and discover Fekrat’s connections and jobs at similar companies. Fekrat has 5 jobs listed on their profile. One patient had mild gastrointestinal disturbance. View Fekrat El Wehedi’s profile on LinkedIn, the world’s largest professional community. There were no significant side effects from pentoxifylline. The visual acuity was not significantly changed at 62 letters (20/128 +2) (Student t-test, P = 0.7) at last follow-up. Cystoid macular edema had improved in 64% (7/11) of eyes at last follow-up as measured by biomicroscopy and optical coherence tomography. The mean follow-up period was 8 months (range, 2.7-16.5 months). The mean duration of pentoxifylline use was 5.3 months (range, 2.5-10.2 months). The mean time from onset of CRVO to start of pentoxifylline therapy was 5 months (range, 1-12 months). The mean best-corrected Early Treatment Diabetic Retinopathy Study visual acuity was 60 letters (Snellen equivalent 20/128) before the initiation of oral pentoxifylline. Statistical analysis of collected data was performed.Įleven patients were identified. Exclusion criteria included nonperfused or indeterminate CRVO, the presence of neovascularization, and previous or concurrent laser therapy or any other treatment for CRVO. Download Arabic songs online from JioSaavn. Fakrt Tol Elyoum, from the album New Year Compilation, was released in the year 2014. Fakrt Tol Elyoum is an Arabic language song and is sung by Jannat. Inclusion criteria included CME, pentoxifylline use for at least 1 month, and a follow-up period of at least 4 months. Singer About Fakrt Tol Elyoum Listen to Fakrt Tol Elyoum online. Retrospective chart review of consecutive patients on pentoxifylline (400 mg po TID) for CRVO was performed. Ellis Wisely, MD, MBA, Julie A.To determine whether oral pentoxifylline, a xanthine-derived hemorheologic agent, decreases cystoid macular edema (CME) and improves visual acuity in eyes with a perfused central retinal vein occlusion (CRVO). Ting, MBBS, Fay Jobe Tripp, MS, OTR/L, CLVT, CDRS, Obinna Umunakwe, MD, PhD, Lejla Vajzovic, MD, Susan M. Seldomridge, MD, MBA, Terry Semchyshyn, MD, Ann Shue, MD, Julia Song, MD, Brian Stagg, MD, Christopher Sun, MBBS, Anthony Therattil, BS, Daniel S.W. Grace Prakalapakorn, MD, MPH, Michael Quist, MD, Leon Rafailov, MD, Roshni Ranjit-Reeves, MD, Nikolas Raufi, MD, William Raynor, BS, Cason Robbins, BS, Ananth Sastry, MD, Dianna L. Mettu, MD, Prithvi Mruthyunjaya, MD, MHS, Nisha Mukherjee, MD, Kenneth Neufeld, MD, Kristen Peterson, MD, James H. Maldonado, MD, Ankur Mehra, MD, Priyatham S. Kesen, MD, Kirin Khan, MD, Wajiha Jurdi Kheir, MD, Jane S. James, OD, Kim Jiramongkolchai, MD, Michael P. Tammy Hsu, MD, Alessandro Iannaccone, MD, MS, FARVO, Charlene L. Glaser, MD, Michelle Sy Go, MD, MS, Mark Goerlitz-Jessen, MD, Herb Greenman, MD, Abhilash Guduru, MD, Preeya Gupta, MD, Renee Halberg, MSW, LCSW, S. Deramo, MD, Cathy DiBernardo, RN, Laura B. Brooks, MD, Pratap Challa, MD, Melissa Mei-Hsia Chan, MBBS, Ravi Chandrashekhar, MD, MSEE, Nathan Cheung, OD, FAAO Claudia S. * what, if anything, you can do to prevent itĪll about Your Eyes includes a glossary of technical terms and, following each entry, links to websites where further information may be found.Ĭontributors. * provide up-to-date information on surgeryįor each eye problem, the authors describe in simple, straightforward language: * describe various eye diseases, including pink eye, cataract, glaucoma, age-related macular degeneration, and diabetic retinopathy * explain eye anatomy and how healthy eyes work In this reliable guide, leading eye care experts: Labor and Working-Class History AssociationĪ concise, easy-to-understand reference book, the revised and updated second edition of All about Your Eyes tells you what you need to know to care for your eyes and what to expect from your eye doctor.Association for Middle East Women's Studies.Author Resources from University Presses.Permissions Information for Journal Authors.Journals fulfilled by DUP Journal Services.
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Pilgrim House follows any required Provincetown Covid-19 mandates. What are your latest vaccination and mask requirements? DIVAS BY THE SEA: DRAG BRUNCH Date: Time: 11 AM : 0 minutes The Divas By The Sea are Drag Brunch Sunday with a fierce new show served with a mouthwatering brunch. We can exchange your ticket(s) for another event or performance date as long as the price of the ticket (seating section) is the same.Įxchanges may be made up to 24 hours before showtime. May I exchange my ticket(s) for another performance? Sorry, all sales are final, there are no refunds, and we do not buy back unused tickets. Be shore to swim up to the weekend Divas by the Sea drag brunch, too, where you can dive into an all-you-can-eat buffet while powerhouse drag artists Roxy. No, there is no waiting list or cancellation list. Provincetowns premiere waterfront venue in the center of town offers the best in lodging, dining and entertainment like no one else. Is there a waiting list or a cancellation list? Seating guests who arrive late is at the discretion of the Showroom staff, and you will be seated in the least disruptive seats available, and late-arrival seats may not be in the section that you purchased. This sensational Sunday Service begins with a buffet to fuel. We encourage all guests to arrive at least 30 minutes early to all shows. If one group member can purchase tickets for all members, that is the easiest way to ensure everyone can sit together. It is usually not possible to accommodate group seating requests at the door the night of the show. If tickets are purchased separately, can we still sit together? Plus, with floor-to-ceiling windows that overlook Commercial Street, you can sip mimosas and savor some of. Large parties (4 or more guests) should arrive early to ensure that your entire party can sit together. Go all in, or pair half-orders with savory brunch favorites like lobster cake benedict. 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The cookies is used to store the user consent for the cookies in the category "Necessary". The name amethyst comes from the Greek word. Wholesale 2ps Natural Amethyst Ear Plugs Bead 8mm 10mm 14mm 16mm 19mm 22mm 25mm Plugs,Boddy Jewerly puncture Jewelry Stone Bead Shipping: US 6.25 From China. This cookie is set by GDPR Cookie Consent plugin. Purple Natural Amethyst Stone is found in a variety of colors, but the most popular is the deep purple hue. The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". The cookie is used to store the user consent for the cookies in the category "Analytics". This cookie is set by GDPR Cookie Consent plugin. and fit in each hole two taper plugs with the broad ends inside. is largely produced by heating natural amethyst of brownish hue. These cookies ensure basic functionalities and security features of the website, anonymously. presses india - rubber plugs on to the borerods and effects a watertight joint. Necessary cookies are absolutely essential for the website to function properly. Contact pins may be sheathed with insulation over part of their length, so as to reduce exposure of energized metal during insertion or removal of the socket. Sockets may be recessed and plugs designed to fit closely within the recess to reduce risk of a user's fingers contacting the live pins. Plugs are shaped to prevent finger contact with live parts. Protection from accidental contact ĭesigns of plugs and sockets have gradually developed to reduce the risk of electric shock and fire. ( May 2021) ( Learn how and when to remove this template message) Unsourced material may be challenged and removed. Please help improve this article by adding citations to reliable sources in this section. This section needs additional citations for verification. Depending on the supply system, one or both current-carrying connections may have significant voltage to earth ground. Single-phase sockets have two current-carrying connections to the power supply circuit, and may also have a third pin for a safety connection to earth ground. To reduce the risk of electric shock, plug and socket systems have safety features in addition to the recessed contacts of the energised socket.Ī socket may be surrounded by a decorative or protective cover which may be integral with the socket. Some plugs have built-in fuses for safety. Some plugs have female contacts that are used only for an earth ground connection. The plug is a male connector, often with protruding pins that match the openings and female contacts in a socket. Typically no energy is supplied to any exposed pins or terminals on the socket, for safety.Ī plug is the movable connector attached to an electrically operated device, and the socket is fixed on equipment or a building structure and connected to an energised electrical circuit. Clockwise from top left: CEE 7/4 (German) plug a matching CEE 7/3 socket with exposed earth (ground) projections on circumference of socket CEE 7/5 (French) socket with projecting earth pin. Plugs and sockets may sometimes combine male and female contacts. Some multi-standard sockets allow use of several types of plug improvised or unapproved adaptors between incompatible sockets and plugs may not provide the full safety and performance of an approved socket-plug combination. Coordination of technical standards has allowed some types of plug to be used across large regions to facilitate trade in electrical appliances, and for the convenience of travellers and consumers of imported electrical goods. Today there are about 20 types in common use around the world, and many obsolete socket types are found in older buildings. A proliferation of types developed for both convenience and protection from electrical injury. Plugs and sockets for portable appliances became available in the 1880s, to replace connections to light sockets with wall-mounted outlets. Different standard systems of plugs and sockets are used around the world. Electrical plugs and sockets differ from one another in voltage and current rating, shape, size, and connector type. AC power plugs and sockets connect electric equipment to the alternating current (AC) mains electricity power supply in buildings and at other sites. However, you can find free PDF to Word converters that are largely focused on document conversion across a broad pool of formats - mostly these PDF converters are browser-based, rather than downloadable software. Generally, they'll all convert to the popular filetypes, with some variations and extras, such as converting PDF to JPG, depending on the platform. It's just one of many different tools they feature, like OCR software and eSign software. Will a PDF editor convert PDFs to Word?Īlmost all PDF editors include conversion tools. So, if the increased workflow proves productive, it may be worth budgeting for an upgrade or paid-for converter. If only certain departments are regularly using PDFs beyond document conversions, a fully featured PDF editor may be the better option.įinally, while there are plenty of free PDF to Word converters, they often come with certain limitations on what you can do, and how often you do it. If your organization runs on Microsoft 365 apps, then a quick-and-easy converter capable of running all popular programs is a must - but an online one may be best, for broader accessibility. It's also worth looking at who will be converting PDFs to Word. And if you’re looking to convert sensitive documents, you'll want to pick a converter that can be installed on your computer and accessed locally. Converting an image-heavy PDF? Choose an app that doesn’t compromise on image quality. If you’re converting multiple files, you’ll want to pick a converter that supports bulk conversions. While modern browsers are some of the best free PDF readers you can get - seriously - they don’t do much beyond highlighting and saving. When considering which free PDF to Word converter is best, you’ll want to take into account what your conversion needs are. Why you can trust TechRadar We spend hours testing every product or service we review, so you can be sure you’re buying the best. Professional PDF power-users, however, will need to explore the platform’s premium monthly and annual subscriptions. If you’re a casual user, that might not be an issue. When we tried out the service, we were impressed to find “simplifies and streamlines online PDF editing and converting, while packing in plenty of extra tools you didn't know you needed until now.”īut we noted the free version comes with a severe limitation: you can only perform one task per hour. That comprehensive toolset alone earned it a place on our best free PDF editors guide. In total, the platform packs in 47 tools - from PDF compressors and mergers, to protecting and watermarking files. Converting from PDF offers up 10 options, including PDF to Word, Excel, PowerPoint, JPG, and OCR. You’ll find 19 ‘convert to PDF’ tools, with support for images, Office software, and even eReader formats. It’s impressively quick and easy.īut PDF Candy is more than just a PDF to Word converter. You can then download it, or upload to your cloud storage. The file will automatically begin converting. Add your file - uploaded from the desktop, or via your DropBox or Google Drive cloud storage. 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PDF editors are one of the most common ways to convert files - it’s just one of many tools in the kit-bag, so if you’re a power-user, it might make sense to explore the likes of Adobe Acrobat.įor more options, it's worth exploring the best free PDF editors and online PDF to Word converters. With free PDF to Word converters, everyone in your organization can access the documents they need. Most PDF conversion tools aren’t limited to one filetype - they let you convert PDFs to Microsoft Word, as well as converting Excel, Powerpoint, and other Office applications (and back again). That said we did have to have a couple of goes and make the prompt more specific – when we originally asked ChatGPT for a “film in which the main character is trained by an alien” it pitched Lilo & Stitch the 2002 animated Disney film. Posing the same question to ChatGPT instead gets it to predict the film I’m thinking of is Star Wars: Episode V The Empire Strikes Back – which it was. There’s a swamp sure, and weird creatures but that’s not the film I’m thinking of. This can be super helpful if you remember snippets of a film scene, the odd line of a song, or some other slightly obscure but specific detail that isn’t the name of the thing you want to recall.Ĭase in point, if you use Google to search for “What's the film in which the main character trains with a small green alien in a swamp” the first film recommendation hidden among the mish-mash of results is Labou – a 2008 flick about kids looking for treasure in the Louisiana bayou. There are reasons for and against using AI chatbots as search engines, but one advantage they do have is that they can have a much better go at piecing together partial information to find what you’re after. AI can’t think critically and their writing will be easily manipulated by any biases in their data set, so make sure you carefully vet and edit anything an AI produces before you release it into the world. Additionally, the show has already been banned on Twitch once after it produced a segment that was transphobic and homophobic – an accident the creators apologized for and blamed on them briefly switching to a ChatGPT alternative to be its writer after ChatGPT suffered from outages. While the show’s segments and jokes may mimic Seinfeld's humor the often nonsense combination of words and inconsistent setups and punchlines help the show avoid being funny and instead see it stray into absurd territory. Nothing, Forever serves as a good example of why you might want to think twice about relying on an AI writer. While at the other end of the spectrum, you have ‘TV shows’ like Nothing, Forever, an AI-written parody of Seinfeld.Ī screenshot from Nothing, Forever it looks like an old PS1 game (Image credit: Mismatch Media) But ChatGPT can take things one step further by just doing the writing for you.īBC Click presenter, Lara Lewington used ChatGPT to help pen a documentary where she outlines how AI could transform our daily lives – and the issues AI has that are holding it back. Writing a TV show – Nothing, ForeverĬhatGPT can be a pretty helpful writing buddy by helping to pitch story prompts, edit your work and even tell you the tone of your writing. Worst case you have to pay the fine anyway, but at least you didn’t waste much of your own time fighting it. Millie Houlton, a student in the UK, reportedly used ChatGPT to send a letter to York City Council which convinced them to withdraw a fine of £60 (around $75 / AU$112), and Shaun Bosley, a UK motorist, used ChatGPT help him reduce a fine for stopping at Gatwick Airport from £100 to £15 (around $125 to $19 / AU$186 to AU$28).Ĭopying this ChatGPT example won’t always help you save money – especially if you don’t double-check that its writing hasn't strayed into gibberish – but considering how quick and easy it is to get the chatbot to produce the letter for you it’s probably worth giving it a try. That’s the thought that’s crossed several people’s minds, with them turning to ChatGPT to help them challenge fines and save money. If parking companies are going to send us automated letters telling us we have to pay a fine, why shouldn’t we leverage AI to send automated arguments back to help us try and reduce how much we’re charged – or even get out of paying completely? Writing letters – get parking fines reduced So while you can have a go at making a game in ChatGPT yourself, don’t expect to make a Wordle-rival like Sumplete on your first try – or even on your 100th. There is also data to support its benefits in certain cancers. Studies on DIM have shown promise for breast health, acne, and reducing PMS. How Does DIM Affect Your Estrogen?ĭIM works at the Phase 1 detox level to help your liver make the most favorable metabolite, 2OHE1 and reduce the excess production of potentially harmful 4OHE1 and 16OHE1. This is why drinking ample water, eating fiber, supporting microbiome health, and ensuring regular bowel movements is so important to your hormone health. Many people mistakenly think that the liver is the only organ involved in estrogen metabolism and while it is very important, so is the health of your kidneys and bowels. In Phase 2 detox these metabolites are methylated and prepared for excretion via the kidneys and bowels. The other metabolites, 4OHE1 and 16OHE1 are associated with unfavorable growths of breast and uterine tissue, including cancer. The most favorable of the three is 2OHE1. Within the liver there are two steps to estrogen metabolism known as Phase 1 and Phase 2 detox.ĭuring Phase 1 your liver converts estrogen into 3 metabolites-2 hydroxy estrone (2OHE1), 4 hydroxy estrone (4OHE1), and 16 hydroxy estrone (16OHE1). When your body no longer needs estrogen it is the liver’s job to package it up so it can be sent out via the urine and stool. To understand how DIM supports your estrogen we first have to understand how estrogen is metabolized. Problems can arise when there is too much estrogen circulating in our bodies or the wrong metabolites. So the goal would not be to drop estrogen as low as possible. But, like all hormones, it needs to be balanced. I know estrogen is often demonized, but we need estrogen! It’s an essential hormone for women, and is responsible for so much good stuff - like cognition, protecting our bones, and helping us have healthy pregnancies. In some instances, estrogen can look normal in labs but the metabolites that are produced in the liver can be problematic. Symptoms of estrogen dominance can include: This can result from the ovaries or other tissues producing too much estrogen, testosterone being converted into estrogen, or from poor metabolism of estrogen itself. Estrogen dominance could unfortunately come about for various reasons: anovulation (no ovulation), stress, adrenal issues, excess fat in the body, the environment, digestive problems, and autoimmune conditions. I’ve written at length about estrogen dominance and the impact it may have on the body. there is not enough progesterone to oppose estrogen). Put simply, estrogen dominance refers to a situation where there is too much estrogen in the body in general or when there is too much estrogen relative to progesterone (i.e. Estrogen imbalance or excess estrogen, often called “estrogen dominance” can lead to a cascade of undesirable symptoms like hormonal headaches, breast tenderness, and PMS, to name a few. One of the most significant things DIM may do for women is improve estrogen metabolism. Hair loss, or hair popping up where you don’t want it.Difficulty with weight gain on your hips, butt, or thighs.
So make sure to do enhancements for your base camp, and it needs to be done with money and the rewards you earn from this game. If you have a 2 tier fight club, when you are done with your base camp level, it will be raised into the third tier. When you increase this base camp, it will result in raising the other building tiers which you have constructed. So if you want to have more of them, you need to do some level-ups for this base camp. Know that in the City of Crime: Gang Wars, base camp is the place that hides gold and money. Once you start in this game, you will be starting it off with this base camp, and every other thing has to be built with the levels you progress. One of the best guidance we can provide you from this City of Crime: Gang Wars tips guide is to do as much as enhancements for your base camp since it is the core place to make you more powerful for the gameplay. So if you are looking for the perfect fight, you know what to do now. The other thing is that when you fight, if it takes much effort with many repeating actions like attacking, simply go with the Keyboard Macro, where you are going to set one key to these all annoying repeating movements. Here you can literally have the chance to set shortcuts for the easiest controls you see, so you will not going to face harder in any phase of your fighting. There is a specific feature coming with this best emulator, which will contribute to your fighting, called Keyboard Mapping. There is only a simple thing to do here, and you only need the best android emulator: LDPlayer. Perfect fighting in the City of Crime: Gang Wars is somewhat hard to deal with but let us introduce you to a way to do it from the City of Crime: Gang Wars tips guide. Upgrading and constructing your weapons best can help you do much better in your gameplay. So in the City of Crime: Gang Wars, you must have some reasonable weapons with you. Armories can provide players with weapons, and weapons are the primary sources for committing a crime. Next, you have to pay the best attention to your armory as we recommend it to you from the City of Crime: Gang Wars tips guide. When these two are increased, it is going to contribute well towards combat as well. You can enter this club as it teaches you the exact way to fight, and when you have perfectly mastered the fighting, you can increase your power as well as the battery. So one of the first places we recommend you construct is the Fight Club. Upgrading can also be done by training some other self-defense activities as they are helping a player to survive this game. So if you want to have a better upgrade from this game, you have first to do the training for your character, and it needs to be done with the combats. The very first thing that you will do when you log in to this game is to select a character, and this character is the one who will engage in many activities to progress you from the gameplay. The first thing that we are going to talk about from the City of Crime: Gang Wars tips guide is the way how you can upgrade yourself. So here is your guide and let's start the journey. With so many fights happening with the worldwide players and a need to be a king to the whole world, you need to be well adjusted for this gameplay, which makes it very important to know about the City of Crime: Gang Wars tips. You need to have the best decisions taken from the entire gameplay as a player because those are the deciding factors for the end result in this game. The game is purely running on the strategy genre, and this game has been introduced to the world by a new game developer called FingerFun. How to Upgrade Yourself in the City of Crime: Gang Wars?Ĭity of Crime: Gang Wars is not your usual RPG game, and you know, every month, the gaming world is filled with different RPG titles, and this one is set to give you a new experience. This is your City of Crime: Gang Wars tips guide to make your gameplay more successful. It is your time to defeat the enemies and if you want to have some best ideas to do it, keep reading. There are many thrilling fights to deal in here, and they all need the best strategies to do better with the gameplay. Do you ever want to be a part of a gangster where you have brothers with you to give support? Then it is a gangster strategy game. If you update the BIOS without doing this, you may lose data if the encryption is looking for the old BIOS. Suspend Bitlocker Encryption if you have it enabled in Windows. Copy the BIOS file to a USB Flash drive that has a FAT32 partition.Ģ. If you see a BIOS that's labeled as "beta," I'd recommend going with the most recent file before that one.ģ. The web navigation experience will be different on each manufacturers' site.Ģ. In the case of my Asus ROG Strix X570-E motherboard, I searched for the product page on Google, clicked the support tab on the page and then found the BIOS under the "Driver & Tools" tab. Find the file on the manufacturer's support / downloads page for your product. If you're using Windows software to update your BIOS (not recommended), it will do the downloading for you.ġ. How to Find a BIOS Update Fileīefore you can update your BIOS, you obviously need to get the latest version, which is usually available as a single file to download from your motherboard manufacturer or PC OEM. You will then need to check and re-enter these values after the BIOS update. You can take screenshots of most BIOS setup menus by inserting a USB Flash drive and hitting the F12 key. If you've changed any of the BIOS's default settings, whether it's for custom overclocking, enabling XMP, setting RAM timings or just changing the boot order of your drives, make sure to write your choices down or take screenshots of the BIOS menus before you update. Updates often wipe out any settings you're changed in the BIOS and return them to their default values. Before You Update: Write Down or Screenshot Your Settings If the code looks wrong and doesn't match the BIOS version numbers on the manufacturer's site, you can get a more reliable result by going directly into the BIOS and looking at the interface. Note that some motherboards may not accurately report their version number to Windows. The best method for most circumstances is updating via the BIOS, because the Windows method, while convenient, introduces greater possibilities for error that could result in non-functioning motherboard. However, these are riskier to use because if Windows crashes during the process, you could have problems. Update via Windows software: Some companies have software that lets you initiate an update from within the OS. You'll need BIOS Flashback if your motherboard won't support your new CPU until it gets a BIOS update. You just put the BIOS update files on a Flash drive (you definitely don't need one of the best flash drives for this), plug it into a specific port on the motherboard, press a button and wait a couple of minutes while some lights flash. BIOS Flashback: Available on some higher-end motherboards, this allows you to update without booting the PC or even having a CPU installed.Update via the BIOS / UEFI environment: Boot into the PC's BIOS (aka UEFI) environment and use the menus there to load the BIOS update that you've put onto a USB Flash drive. |
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